ABSTRACT
Viral-host protein-protein interaction (VHPPI) prediction is essential to decoding molecular mechanisms of viral pathogens and host immunity processes that eventually help to control the propagation of viral diseases and to design optimized therapeutics. Multiple AI-based predictors have been developed to predict diverse VHPPIs across a wide range of viruses and hosts, however, these predictors produce better performance only for specific types of hosts and viruses. The prime objective of this research is to develop a robust meta predictor (MP-VHPPI) capable of more accurately predicting VHPPI across multiple hosts and viruses. The proposed meta predictor makes use of two well-known encoding methods Amphiphilic Pseudo-Amino Acid Composition (APAAC) and Quasi-sequence (QS) Order that capture amino acids sequence order and distributional information to most effectively generate the numerical representation of complete viral-host raw protein sequences. Feature agglomeration method is utilized to transform the original feature space into a more informative feature space. Random forest (RF) and Extra tree (ET) classifiers are trained on optimized feature space of both APAAC and QS order separate encoders and by combining both encodings. Further predictions of both classifiers are utilized to feed the Support Vector Machine (SVM) classifier that makes final predictions. The proposed meta predictor is evaluated over 7 different benchmark datasets, where it outperforms existing VHPPI predictors with an average performance of 3.07, 6.07, 2.95, and 2.85% in terms of accuracy, Mathews correlation coefficient, precision, and sensitivity, respectively. To facilitate the scientific community, the MP-VHPPI web server is available at https://sds_genetic_analysis.opendfki.de/MP-VHPPI/.
ABSTRACT
The emergence of various types of commercial cameras (compact, high resolution, high angle of view, high speed, and high dynamic range, etc.) has contributed significantly to the understanding of human activities. By taking advantage of the characteristic of a high angle of view, this paper demonstrates a system that recognizes micro-behaviors and a small group discussion with a single 360 degree camera towards quantified meeting analysis. We propose a method that recognizes speaking and nodding, which have often been overlooked in existing research, from a video stream of face images and a random forest classifier. The proposed approach was evaluated on our three datasets. In order to create the first and the second datasets, we asked participants to meet physically: 16 sets of five minutes data from 21 unique participants and seven sets of 10 min meeting data from 12 unique participants. The experimental results showed that our approach could detect speaking and nodding with a macro average f1-score of 67.9% in a 10-fold random split cross-validation and a macro average f1-score of 62.5% in a leave-one-participant-out cross-validation. By considering the increased demand for an online meeting due to the COVID-19 pandemic, we also record faces on a screen that are captured by web cameras as the third dataset and discussed the potential and challenges of applying our ideas to virtual video conferences.